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“We can do a lot more to aging’

We are becoming older but also get more and more lessons. Several researchers save the hands to decline to recognize, to slow down and restore. They received 8.5 million euros. Nine questions to professor Eline Barrier, professor of Molecular Epidemiology at the leiden university medical center.

What exactly is the purpose of the research?

Barrier: “DuSRA-VOILA, as the research is called, is the largest collaboration of experts from research institutions and industry in the field of aging.”

“We want to figure out what factors contribute to healthy and vital aging. And understand why some people long vital, and others already in middle age suffer from multiple geriatric ailments.”

“Our research focuses on three pillars: decline in the elderly previously recognize, wear and tear, braking, and damage repair. The ultimate goal is that elderly have more years in health spending.”

Hear that decline is not just?

“Old age is indeed associated with physical wear and tear. But not all the decline is inevitable. Good nutrition, exercise, a healthy biorhythms, and not too much stress on your cells and tissues and may prevent damage.”

Good nutrition and movement can damage cells and tissue prevent. ()

But we know that already? What is the added value of your research?

“That our lifestyle is important for health, it is indeed generally known. But general advice is not for everyone.”

“The condition of the elderly differ greatly from each other, there is a lack of research into personal decline”
Prof. Eline Barrier, professor of Molecular Epidemiology LUMC

“Getting old is a personal process. Therefore, different from the condition of the elderly greatly from each other. Much more than those of a year or thirty. There is a lack of research into personal decline. Up to now, so.”

How can it be that the biological differences become larger as we age?

“By our genes, we differ already huge at birth, but the role of our genes, the life expectancy is much smaller than many people think. In the second half of our lives, our lifestyle and environment weigh heavier.”

“The amount of movement, sleep, stress and nutrition requirements after the lapse of years their toll”
Prof. Eline Barrier, professor of Molecular Epidemiology LUMC

“How much we move and sleep, the amount of stress in life we have experienced, how healthy we have always eaten, what our physical or mental has happened: all those factors go over the years will take their toll. The biology varies, because our lives are very different.”

And with the research you carry that differences in map?

“We want to examine what vijftigplussers at risk of rapid aging. All elderly people with a condition present largely the same advice, treatments and medications, while they are very mixed reactions to it. The differences we want in advance to be able to predict.”

The elderly often get the same advice, treatments and medications. While there, they vary to comment. (Photo: 123RF)

How do you do that?

“We are doing research to signal substances in the blood that the biological age would indicate. We look specifically to how the condition of the intestines, muscles, metabolism and the immune system. That largely determines how fast you age.”

What can we do with that knowledge?

“Then we can not only say that someone is more at risk, for example, dementia and heart failure than his neighbor, but also give advice on what he can personally do to reduce the risk.”

“In the future we will hopefully people have a personal life style advice to give”
Prof. Eline Barrier, professor of Molecular Epidemiology LUMC

“In the future we will hopefully people have a personal life style advice for optimal health of muscles, intestines, metabolism, and immune system. Thus we can have multiple diseases at the same time, slow down.”

Slow or prevent, okay. But is damage caused by old age is also really to fix?

“From animal models shows that there is in the older, damaged cells arise that dust particles secrete which tissues are affected. Therefore, the lessons arise, such as osteoarthritis, cancer, and heart failure.”

“People have that substances also. For people who already have been damaged by aging, we are developing treatments for outdated cells to remove from those tissues. We can do much more tinkering with the aging more than we thought.”

“We can be much more tinkering with ‘older’ than we thought”
Prof. Eline Barrier, professor of Molecular Epidemiology LUMC

So we are all 130?

“That is absolutely not the goal. We focus on healthy ageing: our goal is that people stay healthy longer. Vijftigplussers now have an average of two or three age-related diseases. Therefore, the quality of life and the ‘joie de vivre’ back.”

“Thanks to all of the studies that are currently running, we will people in the future will hopefully be healthy and vital, from fifty to seventy or eighty.”

Prof. Eline Barrier is professor of Molecular Epidemiology connected to the leiden university medical center and chairman of the Dutch Association for the Backed. She leads the research DuSRA-VOILA, that in October start and five years.

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