The Leids Universitair Medisch Centrum (LUMC) to start an investigation of type 1 diabetes. The focus is on insulin-producing beta cells. This study Is a step towards the cure of type 1 diabetes? Eight questions to ask senior member, Françoise Carlotti.
What is type 1 diabetes, exactly?
“Type 1 Diabetes is an autoimmune disease. This means that the immune system makes a mistake. Normally the cleaning up of the immune system, the only illnesses. But sometimes things can go wrong, such as in the case of diabetes type-1.”
What is the problem?
“The immune system attacks the own beta cells that make insulin in the pancreas. It attacks the cells and destroys them. After that, the body produces almost no insulin at all. Without insulin, you can’t live with that, because it regulates the blood sugar levels. The insulin, in turn, are involved in almost all of the stofwisselingsreacties in the body.
The difference between diabetes 1 and 2
Is diabetes type 1 is a little bit different than type 2 diabetes?
“Diabetes type 1 and 2, there are a variety of disorders. In both of these cases, the body’s blood sugar levels are not well controlled with insulin.”
“Diabetes type 2 is to reduce and even to reverse it’
“But there’s one big difference: in the case of diabetes type-2, the reaction body does not have good insulin due to insulin resistance, but it is still known as insulin. Type 1 Diabetes is a auto immune disease-the body creates almost no insulin at all. People with type 1 diabetes, a day of insulin, syringes or pump, carry it.”
What are you going to investigate?
“It’s been in the beta cells by the immune system to attack. We have evidence that these cells, under certain conditions, identity can be changed. “We would like to know how the beta cells of of identity and change in the development of type 1 diabetes.”
“We are going to examine in this identiteitsverandering a way to get the beta cells to the attack of the immune system is the cause of type 1 diabetes to survive. This is done together with the research group of Raphael Scharfmann, from the INSERM-Institut Cochin in Paris, france.”
The purpose of the study: injection of insulin, eliminate the need for
How do you research?
“Both the causes and the underlying mechanisms of this special examine. Hopefully we can find a way to do this process, or even to turn around.”
What is the purpose?
“Ultimately, the research could lead to the development of new treatment strategies, products, for type 1 diabetes, where the insulin production of beta cells are repaired and healthy, beta cells are preserved.”
That is, there is still more research to be done into possible solutions for type 1 diabetes?
“There are a lot more people to research into this area. For example, to determine the cause of the immune response in type 1 diabetes. And to find ways to immune response against. Our analysis is that the existing research is an essential add-on.”
So what does this mean for people with type 1 diabetes?
“People who have type 1 diabetes, and can not have a bite to eat without having to calculate the amount of insulin that is needed. That’s a lot of work. They will also have to every day to have their blood sugar measurements, insulin, syringes or pump, carry it.”
“The combination of a slowed immune system, and recovered to its own insulin production would be the use of insulin for people with type 1 diabetes, in the long term is redundant can be made. So far, we haven’t. However, it is the goal of the research is based.”
Francoise Carlotti has been a visiting researcher at the leiden university medical center. The study identiteitsverandering of the beta cells have been financed with 1 million euros from the foundation of the DON, and the Diabetes foundation.