Possible association between antacids and bone fractures in children

Possible association between antacids and bone fractures in children

Children antacids prescribed, would possible have a better chance of getting bone fractures later in childhood.

That, say scientists in a study on 7 may published going to be during the Pediatric Academic Societies Meeting.

Researchers analysed the records of 874.447 healthy children who were born within the Military Healthcare System (MHS) between 2001 and 2013, who have at least two years, any form of treatment or care received.

The scientists found that ten percent of the children in the first year of life antacids. This is the histamine 2 – receptor antagonists (H2 blockers) such as Zantac, and famotidine as Pepcid and proton pump inhibitors omeprazole (Prilosec) and pantoprazole (Protonix). A protonpompremmer inhibits the operation of the protonpomp, which is responsible for the issuing of gastric acid to the stomach.

Children who protonpomremmers use would according to the researchers, 22 percent more likely to have a fracture, while children of both the inhibitors as H2-blockers use even 31 per cent more likely would have a bone. In the study, no effect was found of the intake of only H2-blockers.


In addition, the researchers found that the number of bone fractures increased as children have a longer period of time the antacids took. The younger was a child that started with the medication, the greater the risk of bone fractures, say researchers. Children who are younger than six months old were walked according to the scientists the greatest risk. Children who after two years of antacids prescribed to us, had no greater risk than children up to the age of five years old no antacids had swallowed it.

“Antacids for adults easy to obtain seem harmless, but in our study seems to substantiate that this medication is not safe for children. Certainly for very young children, the medication should only be prescribed when the symptoms of heartburn are very serious. An example of this is the gastroesophageal reflux disease. When children therefore have to take medication, preferably as short as possible,” says principal investigator Laura Malchodi.


40 to 65 percent of the children with the reflux disease. Often the first symptoms when the child is two to three weeks old. When the child is between four and five months old, are the symptoms the most. Often grows a baby around the first year of life on the reflux disease. In this phase grows in the digestive tract, making symptoms disappear.

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