Mice with 3D-printed ovaries have given birth to healthy mouse pups. After implantedwith the bioprosthetic ovaries, the previously infertile mothers saw an increase in the hormone levels and began to ovulate for the successful setting up and the birth of the young.
The ovaries were 3D-printedthrough an innovative technique, developed by researchers from Northwestern University, whocreated a jetty tohold immature eggs. Although the current technique is designed for the mice, the research team, the ultimate goal is to scale for the man.
“The main motivation is to develop a tissue-engineered replacement for women with a reduced ovarian, Alexandra Rutz, co-lead author of the study, told Digital Trends. “Most of these women have a reduced ovarian are young cancer survivors. It is amazing how far the cancer has come back, but this means that the population of the survivors that could have side effects for the treatment of cancer is increasing. One of those devastating consequences of infertility.
For ink,” the scientists a unique gelatin is biocompatible, strong enough to stand by means of an operation, and is porous enough to integrate with the mice body tissue.
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In men, the researchers plan to take samples of patients with ovarian cells, and the preservation of them before she goes in for treatment. Once in remission, the cells would be inserted into the 3D-printed scaffolding, which would then be implanted in the patient.
“In an ideal future, hospitals will have laboratories for the production of these types of bioprostheses, Rutz said. “This could also be the equipment and personnel for the operation and maintenance of each patient’s own cells, together with a 3D-printer that can be used for the printing of implants of custom shapes, sizes and materials.
The scientists’ next steps is difficult as they are to the scale of the scaffolding up significantly to larger animals. They will also investigate ways to optimize the implants for life-long performance.
A paper detailing the research was published this week in the journalNature Communications.