Immune system bowel can substance that intestinal bacteria will learn to tolerate

Immune system bowel can substance that intestinal bacteria will learn to tolerate

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The immune system in the intestines can be a substance to create, which ensures that billions of bacteria in the body life be tolerated. The substance is free from the degradation of the amino acid, ‘tryptophan’, which is found in meat, bananas, bread and cheese.

This experienced researchers from the department of Gastrointestinal-, Liver – and intestinal diseases of the Erasmus MC.

The degradation of tryptophan in the brain for production of serotonin, which the immune system tells that the tolerant may react with intestinal bacteria.

The discovery of the effect of this substance in the intestines can be a step forward for the treatment of people with intestinal disorders such as Crohn’s disease and irritable bowel syndrome.

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“One of the degradation products of tryptophan, kynurenine, can be seen as a liefdesdrankje to work for the dendritic cells of the immune system. That give under the influence of kynurenine, the message that the immune system, the intestinal cells alone is allowed to leave,” explains the head of the MDL laboratory Maikel Peppelenbosch.

“In people with Irritable bowel Syndrome noticed that they are relatively often products such as dried sausages to eat,” says Peppelenbosch. “Perhaps, conclude that these patients are a kind of natural need of a lot of tryptophan because in the degradation, kynurenine.”


For patients with Irritable bowel Syndrome, or bowel disease such as Crohn’s disease and ulcerative colitis can the discovery is an important step for their treatment. Irritable bowel Syndrome is according to the Erasmus MC is a common problem in the Netherlands. May have 5 to 20 percent of Dutch people there in more or less bothered by it.

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