Two of the piglets recently born in China is similar to the average of the pigs on the outside, but on the inside she is a (small) part of the lake.
A team of researchers has generated the pig-primate organisms, the injection of monkey stem cells into a fertilized pig embryos, and then implanting them into surrogate sows are kept in groups, according to a piece by New Scientist. Two of the resulting piglets have developed between species of animals, known as chimeras, that is, they contained the DNA of two different individuals, and in this case, a pig and a monkey.
“This is the first report of a full term pig, monkey thoughts,” co-author Tang Hai, a researcher at the State Key Laboratory of stem cell and Reproductive Biology in Beijing, told the New Scientist. In the end, Hai’s and the group’s quest to grow human organs in animals for use in transplantation procedures. For now, the team plans to stick with the monkey cells, as well as the development of human-animal chimeras will be presenting a wide range of “ethical issues,” the authors noted in a report published Nov. 28 in the journal Protein & Cell.
To make the pig-primate chimeras, Hai and his co-authors, the first, the cells from cynomolgus monkeys (Macaca fascicularis), in laboratory dishes. The team shifted the cells, the DNA, the insertion of instructions for the construction of a fluorescent protein, allowing the cells to glow bright green. These light-emitting cells that gave rise to lasing from the stem cells, which researchers then injected into a prepared pig embryos. These hot spots, the researchers were able to track the ape to the cells of the embryo grow in the bigs.
Related: The 9 Most Interesting Transplants
A total of 4,000 embryos, a single injection of the monkey’s cells were implanted into surrogate sows. The pigs are a bore 10 of the piglets, as a result of the procedure, but just a few of the descendants are growing, both the pig and the monkey cells. By scanning the spots of fluorescent green, the team found the monkey’s cells have spread to multiple organs, including the heart, the liver, the spleen, the lungs and the skin.
In each and every organ, and is between one in 1,000 and one in 10,000 of the cells turned out to be a monkey’s cells — in other words, the interspecies chimeras have been more than 99% of species.
Although low, the proportion of the monkey, the pig cells are still in the minority, and the maximum number of human cells ever grown in a human-animal chimera. In 2017, scientists have created human-pig chimeras, who grew up just a single human cell, for every 100,000 of the pig cells. The inter-species embryos, which were only to be allowed to develop for a month, in addition to ethical reasons, including concern that the human cells are able to grow in the chimera of the brain, and the rendering of the animal-human-like consciousness, according to the New Scientist.
In spite of ethical scruples, the same team of researchers went on to create a human-ape chimeras, earlier this year, according to a report in the Spanish newspaper El País. The results of a controversial experiment that has not yet been reported but scientists say that there is not a human primate embryos were allowed to develop for more than a couple of weeks, the paper reported.
Hai and his co-authors could have avoided the ethical issues involved with human-animal chimeras, however, an expert, was not impressed with their interspecies birth. Stem cell biologist Paul Knoepfler of the University of California, Davis, told the New Scientist that the low ratio of monkey to the pig cells, seems to be “pretty daunting.” In addition, two of the fantasies, and all of the other piglets died shortly after birth, he noted.
The exact reason for the pigs’ death remains “unclear,” Hai told New Scientist, however, he said that he had reason to suspect that the death is linked to the in-vitro-fertilization (IVF) procedure, instead of injecting monkey DNA. Other researchers have also found that the IVF procedure will work in the pigs, according to a report in 2019 at the latest, in the journal Theriogenology.
In the not too distant future, Hai and his team are striving to increase the proportion of of monkey cells, pig cells, in the the future and fantasies, and eventually it will grow throughout the monkey’s bodies to their pigs, Hai told New Scientist. In their paper, the authors have found that, in pigs, may help to “clear the path” toward the “ultimate goal of the human organ reconstruction in a large animal.”
- Real or Fake? 8 Bizarre Hybrid Animals
- Genetics by the Numbers: 10 Tantalizing Tales
- 7 Diseases You Can Learn from a Genetic Test
Originally published on Live Science.